Methoxychlor May Cause Ovarian Follicular Atresia and Proliferation of the Ovarian Epithelium in the Mouse
نویسندگان
چکیده
منابع مشابه
Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways.
The pesticide methoxychlor (MXC) is a reproductive toxicant that targets antral follicles of the mammalian ovary. Cytochrome P450 enzymes metabolize MXC to mono-OH MXC (1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane [mono-OH]) and bis-OH MXC (1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane [HPTE]), two compounds that are proposed to be more toxic than the parent compound, can inte...
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Throughout ovarian development and function in mammals, a highly orchestrated, periodic process known as follicular atresia occurs that destroys and eliminates follicles and oocytes from the ovary. Follicular atresia is pervasive. In humans, it is estimated to account for 99.9% of the loss of oocytes from development of the fetal ovary until reproductive senescence (Baker, 1963; Faddy et al., 1...
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The reproductive performance of any mammalian species can be enhanced by enriching nutrition, regulating environmental factors like photoperiod, temperature, humidity etc., through selective breeding, endocrine manipulations and better management practices (Sharma, 2000; Maillet et al., 2002; Bussiere et al., 2002; Iwata et al., 2004, 2005; Rudolf, 2007; Bhardwaj and Sharma, 2011). The endocrin...
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In the present study was performed to evaluate the follicular growth and hormonal changes after ovarian artery ligation in rats. Fifty six virgin 90-day–old female rats were used. The rats were chosen from 100 female rats by a vaginal smear, which showed that they were synchronized in estrous phase of the menstrual cycle. Animals were kept in seven cages (n=8 in each) at a temperature of 22 ± 2...
متن کاملEffect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium.
Although the ovarian surface epithelium (OSE) is responsive to hormones and endocrine-disrupting chemicals, little information is available on the metabolizing capabilities of the OSE. Thus, we tested the hypothesis that the OSE is capable of expressing genes regulating phase I metabolism of estrogen and the estrogenic endocrine disruptor methoxychlor (MXC). To test this hypothesis, we isolated...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2002
ISSN: 1096-0929
DOI: 10.1093/toxsci/68.2.473